Studies on the disturbances of the cerebral blood circulation.

The studies on the disturbances of cerebral blood circulation have been made by the writer and his coworkers since 1955.(1-9) In this work, new findings of the cerebral vascular architecture (both arteries and veins) were obtained with the methods of acrylic resin injection into the cerebral vessels.(3.7) From the view of the cerebral vascular architecture, a pathogenesis of cerebral hemorrhages in the cases of leukemia and aplastic anemia, mechanisms and common sites of the cerebral softening and hemorrhage due to venous circulatory disturbances will be explained. This type of hemor rhages can be called "edematous necrotic hemorrhages." In the experiment, the similar edematous necrotic hemorrhages were observed in the brains of anemic dogs with venous circulatory disturbances. (3, 8) In addition to the anatomical pathologic studies of the spontaneous hemorrhages and softenings of the human beings, the ligations of the anterior and middle cerebral arteries of dogs with either increased or decreased blood pressure were performed. (6,9) On the bases of these observations, the followings will be discussed; the cerebral vascular architec ture, arterial and venous cerebral softenings and hemorrhages and what an im portant role the pathologic blood vessels play in these conditions, especially angionecrosis.